Abstract
An efficient strategy using Rh(I)-catalyzed [(3 + 2) + 1] cycloaddition of 1-ene-vinylcyclopropane and CO as a key step to build the cis-hydrodibenzofuran skeleton has been developed and applied for the formal synthesis of (±)-galanthamine and (±)-lycoramine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amaryllidaceae Alkaloids / chemical synthesis*
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Amaryllidaceae Alkaloids / chemistry*
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Benzofurans / chemistry*
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Catalysis
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Cycloaddition Reaction
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Galantamine / chemical synthesis*
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Galantamine / chemistry*
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Molecular Structure
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Rhodium / chemistry*
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Stereoisomerism
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Vinyl Compounds / chemistry*
Substances
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Amaryllidaceae Alkaloids
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Benzofurans
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Vinyl Compounds
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Galantamine
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Rhodium
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lycoramine