Assessment of RIT2 rs12456492 association with Parkinson's disease in Mainland China

Neurobiol Aging. 2015 Mar;36(3):1600.e9-11. doi: 10.1016/j.neurobiolaging.2014.12.012. Epub 2014 Dec 13.

Abstract

A recent meta-analysis of genome-wide association studies in Parkinson's disease (PD) has identified the rs12456492 variant in RIT2 as a new susceptibility loci. Because the characteristics of this locus in a Han Chinese population from mainland China was still unknown, we performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals. In total, 933 subjects comprising 460 PD patients and 473 control subjects were genotyped. We found a significant difference in the distributions of genotype and allele between PD and control groups (genotype p = 0.008, allele p = 0.007, odds ratio = 1.296, 95% confidence interval = 1.075-1.563). This study replicates the association between rs12456492 variant and risk of developing PD in a Han Chinese population.

Keywords: Chinese Han population; GWAS; Parkinson's disease; RIT2; rs12456492.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Asian People / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genome-Wide Association Study*
  • Genotype
  • Humans
  • Male
  • Meta-Analysis as Topic
  • Middle Aged
  • Monomeric GTP-Binding Proteins / genetics*
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Risk

Substances

  • Monomeric GTP-Binding Proteins
  • RiT2 protein, human