Use of granulocyte colony-stimulating factor during pregnancy in women with chronic neutropenia

Obstet Gynecol. 2015 Jan;125(1):197-203. doi: 10.1097/AOG.0000000000000602.


Objective: To report outcomes associated with the administration of granulocyte colony-stimulating factor (G-CSF) to women with chronic neutropenia during pregnancy.

Methods: We conducted an observational study of women of childbearing potential with congenital, cyclic, idiopathic, or autoimmune neutropenia enrolled in the Severe Chronic Neutropenia International Registry to determine outcomes of pregnancies, without and with chronic G-CSF therapy, 1999-2014. Treatment decisions were made by the patients' personal physicians. A research nurse conducted telephone interviews of all enrolled U.S. women of childbearing potential using a standard questionnaire. Comparisons used Fisher's exact test analysis and Student's t test.

Results: One hundred seven women reported 224 pregnancies, 124 without G-CSF therapy and 100 on chronic G-CSF therapy (median dose 1.0 micrograms/kg per day, range 0.02-8.6 micrograms/kg per day). There were no significant differences in adverse events between the groups considering all pregnancies or individual mothers, for example, spontaneous terminations (all pregnancies: no G-CSF in 27/124, G-CSF in 13/100; P=.11, Fisher's exact test), preterm labors (all pregnancies, no G-CSF in 9/124, G-CSF in 2/100, P=.12). A study with at least 300 per group would be needed to detect a difference in these events with 80% statistical power (α=0.05). Four newborns of mothers with idiopathic or autoimmune neutropenia not on G-CSF (4/101) had life-threatening infections, whereas there were no similar events (0/90) in the treated group, but this difference was also not statistically significant (P=.124). Adverse events in the neonates were similar for the two groups.

Conclusion: This observational study showed no significant adverse effects of administration of G-CSF to women with severe chronic neutropenia during pregnancy.

Level of evidence: III.

Publication types

  • Observational Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Abortion, Spontaneous / epidemiology
  • Adolescent
  • Adult
  • Female
  • Gestational Age
  • Granulocyte Colony-Stimulating Factor / therapeutic use*
  • Humans
  • Infant, Newborn
  • Infections / epidemiology
  • Leukocyte Count
  • Live Birth
  • Neutropenia / blood
  • Neutropenia / drug therapy*
  • Neutrophils*
  • Obstetric Labor, Premature / epidemiology
  • Pregnancy
  • Pregnancy Complications, Hematologic / blood
  • Pregnancy Complications, Hematologic / drug therapy*
  • Young Adult


  • Granulocyte Colony-Stimulating Factor

Supplementary concepts

  • Neutropenia, severe chronic