Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor

ACS Nano. 2015 Jan 27;9(1):696-707. doi: 10.1021/nn506137n. Epub 2015 Jan 12.


Here, we present a precision cancer nanomedicine based on Bi(2)S(3) nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi(2)S(3) NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi(2)S(3) NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.

Keywords: Bi2S3 nanorods; X-ray computed tomography; multispectral optoacoustic tomography; photothermal therapy; thin bandgap semiconductor.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bismuth / chemistry*
  • Cell Line, Tumor
  • Male
  • Mammary Neoplasms, Experimental / diagnosis*
  • Mammary Neoplasms, Experimental / pathology
  • Mammary Neoplasms, Experimental / therapy*
  • Mice
  • Multimodal Imaging*
  • Nanotubes*
  • Photoacoustic Techniques
  • Phototherapy*
  • Sulfides / chemistry*
  • Theranostic Nanomedicine / methods*
  • Tomography, X-Ray Computed


  • Sulfides
  • Bismuth
  • bismuth sulfide