Osteoimmunology in 2014: Two-faced immunology-from osteogenesis to bone resorption

Nat Rev Rheumatol. 2015 Feb;11(2):74-6. doi: 10.1038/nrrheum.2014.219. Epub 2015 Jan 6.


Even though activation of immunity is associated with bone destruction, new mechanisms have been described in 2014 through which immunology-associated pathways can cooperate to support osteogenesis. These advances support the view of the immune system as a central mechanism which can regulate bone homeostasis, regeneration and destruction.

MeSH terms

  • Animals
  • Bone Remodeling / immunology
  • Bone Resorption / immunology*
  • Humans
  • Neovascularization, Physiologic / immunology
  • Osteogenesis / immunology*
  • Scleroderma, Systemic / immunology*
  • T-Lymphocytes, Regulatory / immunology