A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways

Curr Opin Biotechnol. 2015 Aug;34:110-7. doi: 10.1016/j.copbio.2014.12.007. Epub 2015 Jan 3.


In multicellular organisms, individual cells have evolved to sense external and internal cues in order to maintain cellular homeostasis and survive under different environmental conditions. Cells efficiently adjust their metabolism to reflect the abundance of nutrients, energy and growth factors. The ability to rewire cellular metabolism between anabolic and catabolic processes is crucial for cells to thrive. Thus, cells have developed, through evolution, metabolic networks that are highly plastic and tightly regulated to meet the requirements necessary to maintain cellular homeostasis. The plasticity of these cellular systems is tightly regulated by complex signaling networks that integrate the intracellular and extracellular information. The coordination of signal transduction and metabolic pathways is essential in maintaining a healthy and rapidly responsive cellular state.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Homeostasis
  • Metabolic Networks and Pathways
  • Protein Kinases / metabolism
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / metabolism


  • Protein Kinases
  • TOR Serine-Threonine Kinases