A role for AT1 receptor-associated proteins in blood pressure regulation

Curr Opin Pharmacol. 2015 Apr;21:43-7. doi: 10.1016/j.coph.2014.12.009. Epub 2015 Jan 3.

Abstract

The renin angiotensin-system is one of the most important humoral regulators of blood pressure. The recently discovered angiotensin receptor-associated proteins serve as local modulators of the renin angiotensin-system. These proteins interact with the AT1 receptor in a tissue-specific manner and regulate the sensitivity of the target cell for angiotensin II. The predominant effect of the AT1 receptor-associated proteins on angiotensin II-induced signaling is the modulation of the surface expression of the AT1 receptor. This review provides an overview of our current knowledge with respect to the relevance of AT1 receptor-associated proteins for blood pressure regulation. Two aspects of blood pressure regulation will be discussed in detail: angiotensin II-dependent volume homoeostasis and vascular resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology*
  • Animals
  • Blood Pressure / physiology*
  • Humans
  • Receptor, Angiotensin, Type 1 / physiology

Substances

  • AGTRAP protein, human
  • Adaptor Proteins, Signal Transducing
  • Receptor, Angiotensin, Type 1