Recent Advances Bioactive 1,2,4-triazole-3-thiones

Eur J Med Chem. 2015 Jun 5;97:830-70. doi: 10.1016/j.ejmech.2014.11.033. Epub 2014 Nov 26.

Abstract

Triazoles are heterocyclic compounds which have a five-membered ring of two carbon atoms and three nitrogen atoms. These structures have been interest in the development of novel compounds with anticonvulsant, antidepressant, antioxidant, anti-inflammatory, analgesic, antinociceptive, antibacterial, antimycobacterial, antifungal, antiviral, anticancer, anti-parasitic, anti-urease and other activities. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. This review contains various pharmacological activities of 1,2,4-triazole-3-thiones in one place and it is also the milestone for the new research towards this moiety.

Keywords: 1,2,4-Triazole-3-thione; Anastrozole; Diflunisal 1,2,4-triazole; Etodolac 1,2,4-triazole; Fluconazole; Ribavirin.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Discovery / methods*
  • Humans
  • Thiones / chemistry*
  • Thiones / pharmacology*
  • Triazoles / chemistry*

Substances

  • Thiones
  • Triazoles
  • 1,2,4-triazole