Cytokines, IBD, and colitis-associated cancer

Inflamm Bowel Dis. 2015 Feb;21(2):409-18. doi: 10.1097/MIB.0000000000000236.


Inflammatory bowel diseases (IBDs) are debilitating conditions that result in intestinal damage due to chronic inflammation. In addition, the perpetual state of inflammation predisposes individuals to the development of colitis-associated cancer. Because of the immense immune cell infiltration into colon, cytokines produced by immune cells are major players in the initiation and progression of IBD and colitis-associated cancer. In this review, we will explore the functions of many key cytokines and their roles in IBD and colitis-associated cancer, as well as their influences on the immune system and stromal cells. Finally, we will briefly discuss current therapies and current clinical trials targeting cytokines in IBD.

Publication types

  • Review

MeSH terms

  • Animals
  • Colitis / complications*
  • Cytokines / immunology*
  • Humans
  • Immune System / immunology*
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / physiopathology*
  • Neoplasms / etiology*
  • Neoplasms / pathology


  • Cytokines