Discovery and annotation of long noncoding RNAs

John S Mattick; John L Rinn

doi:10.1038/nsmb.2942

Discovery and annotation of long noncoding RNAs

Nat Struct Mol Biol. 2015 Jan;22(1):5-7. doi: 10.1038/nsmb.2942.

Authors

John S Mattick¹, John L Rinn²

Affiliations

¹ Garvan Institute of Medical Research, Sydney, New South Wales, Australia, and St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
² Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA, the Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA, and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

PMID: 25565026
DOI: 10.1038/nsmb.2942

Abstract

Recent advances in RNA-sequencing technologies have led to the discovery of thousands of previously unannotated noncoding transcripts, including many long noncoding RNAs (lncRNAs) whose functions remain largely unknown. Here we discuss considerations and best practices in lncRNA identification and annotation, which we hope will foster functional and mechanistic exploration.

MeSH terms

Gene Expression Regulation*
Molecular Biology / trends
Molecular Sequence Annotation / trends
RNA, Untranslated / genetics*
RNA, Untranslated / physiology*

Substances

RNA, Untranslated