Discovery and annotation of long noncoding RNAs

Nat Struct Mol Biol. 2015 Jan;22(1):5-7. doi: 10.1038/nsmb.2942.


Recent advances in RNA-sequencing technologies have led to the discovery of thousands of previously unannotated noncoding transcripts, including many long noncoding RNAs (lncRNAs) whose functions remain largely unknown. Here we discuss considerations and best practices in lncRNA identification and annotation, which we hope will foster functional and mechanistic exploration.

MeSH terms

  • Gene Expression Regulation*
  • Molecular Biology / trends
  • Molecular Sequence Annotation / trends
  • RNA, Untranslated / genetics*
  • RNA, Untranslated / physiology*


  • RNA, Untranslated