Essential Role for Oxidative Phosphorylation in Cancer Progression

Cell Metab. 2015 Jan 6;21(1):11-2. doi: 10.1016/j.cmet.2014.12.013.


Cancers are often affected by derangements in mitochondrial (mt) function, as well as mtDNA mutations. In this issue, Tan et al. (2015) demonstrate that only mtDNA-depleted cancer cells capable of recovering mtDNA from the host form metastasizing cancers in vivo, revealing an essential requirement for oxidative phosphorylation in tumor progression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Mitochondria / metabolism*