First isolation and genomic characterization of enterovirus A71 and coxsackievirus A16 from hand foot and mouth disease patients in the Lao PDR

V H Nguyen; B Sibounheuang; K Phommasone; M Vongsouvath; P N Newton; G Piorkowski; C Baronti; X de Lamballerie; A Dubot-Pérès

doi:10.1002/nmi2.63

First isolation and genomic characterization of enterovirus A71 and coxsackievirus A16 from hand foot and mouth disease patients in the Lao PDR

New Microbes New Infect. 2014 Nov;2(6):170-2. doi: 10.1002/nmi2.63. Epub 2014 Sep 18.

Authors

V H Nguyen¹, B Sibounheuang², K Phommasone², M Vongsouvath², P N Newton³, G Piorkowski¹, C Baronti⁴, X de Lamballerie¹, A Dubot-Pérès⁵

Affiliations

¹ Aix Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health ; IHU Méditerranée Infection, APHM Public Hospitals of Marseille Marseille, France.
² Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital Vientiane, Lao PDR.
³ Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital Vientiane, Lao PDR ; Centre for Tropical Medicine, Nuffield Department of Medicine, Churchill Hospital, University of Oxford Oxford, United Kingdom.
⁴ Aix Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health.
⁵ Aix Marseille Université, IRD French Institute of Research for Development, EHESP French School of Public Health ; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital Vientiane, Lao PDR ; Centre for Tropical Medicine, Nuffield Department of Medicine, Churchill Hospital, University of Oxford Oxford, United Kingdom.

PMID: 25566395
PMCID: PMC4265048
DOI: 10.1002/nmi2.63

Abstract

Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) are major aetiological agents of hand, foot and mouth disease in Asia. We established the first genomic characterization of strains isolated in 2011 from Lao patients. Isolates were related to EV-A71 genotype C4 and CV-A16 genotype B1a that circulated in neighbouring countries during the same period. This confirms the regional character of hand, foot and mouth disease epidemiology and makes plausible the occurrence of severe disease in the Lao population.

Keywords: Coxsackievirus A16; enterovirus A71; genome sequence; hand, foot and mouth disease.