Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells

Leukemia. 2015 Jun;29(6):1425-9. doi: 10.1038/leu.2015.1. Epub 2014 Jan 8.

Authors

S Kinpara¹, S Ito¹, T Takahata¹, Y Saitoh², A Hasegawa¹, M Kijiyama¹, A Utsunomiya³, M Masuda⁴, Y Miyazaki⁵, M Matsuoka⁶, M Nakamura⁷, S Yamaoka², T Masuda¹, M Kannagi¹

Affiliations

¹ Department of Immunotherapeutics, Tokyo Medical and Dental University, Tokyo, Japan.
² Department of Molecular Virology, Tokyo Medical and Dental University, Tokyo, Japan.
³ Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
⁴ Cancer Centre, University of the Ryukyus Hospital, Okinawa, Japan.
⁵ Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
⁶ Institute for Virus Research, Kyoto University, Kyoto, Japan.
⁷ Human Gene Sciences Center, Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 25567137
DOI: 10.1038/leu.2015.1

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Base Sequence
Blotting, Western
Flow Cytometry
Gene Expression Regulation*
Genome, Viral
Humans
Leukemia-Lymphoma, Adult T-Cell / genetics
Leukemia-Lymphoma, Adult T-Cell / metabolism*
Leukemia-Lymphoma, Adult T-Cell / pathology*
Molecular Sequence Data
NF-kappa B / genetics
NF-kappa B / metabolism*
RNA, Antisense / genetics
RNA, Antisense / metabolism*
RNA, Messenger / genetics
RNA, Viral / genetics
RNA, Viral / metabolism*
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Tumor Cells, Cultured
eIF-2 Kinase / genetics
eIF-2 Kinase / metabolism*

Substances

NF-kappa B
RNA, Antisense
RNA, Messenger
RNA, Viral
eIF-2 Kinase