Abstract
Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Line
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Disease Models, Animal
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Female
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Guinea Pigs
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Herpes Simplex / microbiology*
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Histocytochemistry
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Mutation
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Ribonucleotide Reductases / genetics*
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Simplexvirus / enzymology
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Simplexvirus / genetics*
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Simplexvirus / physiology
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Skin / pathology
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Virus Replication
Substances
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Ribonucleotide Reductases