Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs

Virology. 1989 Dec;173(2):733-5. doi: 10.1016/0042-6822(89)90588-6.

Abstract

Two herpes simplex virus type 1 ribonucleotide reductase null mutants, hrR3 and ICP6 delta, produced cutaneous lesions in guinea pigs as severe as those of wild-type strains. The lesions induced by hrR3 resulted from in vivo replication of the mutant virus, suggesting that this virus-encoded enzyme is nonessential for virus replication in guinea pigs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Disease Models, Animal
  • Female
  • Guinea Pigs
  • Herpes Simplex / microbiology*
  • Histocytochemistry
  • Mutation
  • Ribonucleotide Reductases / genetics*
  • Simplexvirus / enzymology
  • Simplexvirus / genetics*
  • Simplexvirus / physiology
  • Skin / pathology
  • Virus Replication

Substances

  • Ribonucleotide Reductases