On the brink: a new synaptic vesicle release model at the calyx of held

Melissa A Herman; Christian Rosenmund

doi:10.1016/j.neuron.2014.12.038

On the brink: a new synaptic vesicle release model at the calyx of held

Neuron. 2015 Jan 7;85(1):6-8. doi: 10.1016/j.neuron.2014.12.038.

Authors

Melissa A Herman¹, Christian Rosenmund²

Affiliations

¹ Neuroscience Research Center, NeuroCure Excellence Cluster, Charité Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany.
² Neuroscience Research Center, NeuroCure Excellence Cluster, Charité Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: christian.rosenmund@charite.de.

PMID: 25569343
DOI: 10.1016/j.neuron.2014.12.038

Abstract

How vesicle calcium sensors interact with calcium channels at synapses affects neurotransmitter release dynamics. In this issue of Neuron, Nakamura et al. (2015) propose that synaptic vesicles are tightly coupled around the perimeter of a voltage-gated calcium channel cluster.

Publication types

Comment

MeSH terms

Animals
Calcium / metabolism*
Calcium Channels, N-Type / metabolism*
Exocytosis / physiology*
Presynaptic Terminals / metabolism*
Synapses / metabolism*
Synaptic Vesicles / metabolism*

Substances

Calcium Channels, N-Type
Calcium