Clinical and biochemical manifestations of Cushing's

Pituitary. 2015 Apr;18(2):181-7. doi: 10.1007/s11102-014-0631-4.


Introduction: Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality.

Materials and methods: This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particular focus on data from recently published literature.

Conclusion: Obesity and metabolic alterations, hypertension and cardio/cerebrovascular complications, hypercoagulability/thromboembolism, neuropsychiatric, muscle/skeletal and immune consequences remain the most challenging. Cardiovascular consequences and immunosuppression determine the main causes of death in Cushing's syndrome necessitating early intervention when possible.

Publication types

  • Review

MeSH terms

  • ACTH-Secreting Pituitary Adenoma / diagnosis*
  • ACTH-Secreting Pituitary Adenoma / mortality
  • ACTH-Secreting Pituitary Adenoma / therapy
  • Adenoma / diagnosis*
  • Adenoma / mortality
  • Adenoma / therapy
  • Cause of Death
  • Comorbidity
  • Humans
  • Pituitary ACTH Hypersecretion / diagnosis*
  • Pituitary ACTH Hypersecretion / mortality
  • Pituitary ACTH Hypersecretion / therapy
  • Prognosis
  • Risk Assessment
  • Risk Factors
  • Time Factors