Selenium status in U.K. pregnant women and its relationship with hypertensive conditions of pregnancy

Br J Nutr. 2015 Jan 28;113(2):249-58. doi: 10.1017/S000711451400364X. Epub 2015 Jan 9.


Dietary intake/status of the trace mineral Se may affect the risk of developing hypertensive conditions of pregnancy, i.e. pre-eclampsia and pregnancy-induced hypertension (PE/PIH). In the present study, we evaluated Se status in U.K. pregnant women to establish whether pre-pregnant Se status or Se supplementation affected the risk of developing PE/PIH. The samples originated from the SPRINT (Selenium in PRegnancy INTervention) study that randomised 230 U.K. primiparous women to treatment with Se (60 μg/d) or placebo from 12 weeks of gestation. Whole-blood Se concentration was measured at 12 and 35 weeks, toenail Se concentration at 16 weeks, plasma selenoprotein P (SEPP1) concentration at 35 weeks and plasma glutathione peroxidase (GPx3) activity at 12, 20 and 35 weeks. Demographic data were collected at baseline. Participants completed a FFQ. U.K. pregnant women had whole-blood Se concentration lower than the mid-range of other populations, toenail Se concentration considerably lower than U.S. women, GPx3 activity considerably lower than U.S. and Australian pregnant women, and low baseline SEPP1 concentration (median 3.00, range 0.90-5.80 mg/l). Maternal age, education and social class were positively associated with Se status. After adjustment, whole-blood Se concentration was higher in women consuming Brazil nuts (P= 0.040) and in those consuming more than two seafood portions per week (P= 0.054). A stepwise logistic regression model revealed that among the Se-related risk factors, only toenail Se (OR 0.38, 95% CI 0.17, 0.87, P= 0.021) significantly affected the OR for PE/PIH. On excluding non-compliers with Se treatment, Se supplementation also significantly reduced the OR for PE/PIH (OR 0.30, 95% CI 0.09, 1.00, P= 0.049). In conclusion, U.K. women have low Se status that increases their risk of developing PE/PIH. Therefore, U.K. women of childbearing age need to improve their Se status.

Keywords: Hypertension; Hypertensive conditions of pregnancy; Pregnancy; Selenium status.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / analysis
  • Biomarkers / blood
  • Cohort Studies
  • Deficiency Diseases / diet therapy
  • Deficiency Diseases / metabolism
  • Deficiency Diseases / physiopathology*
  • Deficiency Diseases / prevention & control
  • Diet / adverse effects*
  • Dietary Supplements
  • Female
  • Glutathione Peroxidase / blood
  • Humans
  • Hypertension, Pregnancy-Induced / epidemiology
  • Hypertension, Pregnancy-Induced / etiology*
  • Hypertension, Pregnancy-Induced / prevention & control
  • Longitudinal Studies
  • Maternal Nutritional Physiological Phenomena*
  • Nails / chemistry
  • Nutritional Status*
  • Pilot Projects
  • Pre-Eclampsia / epidemiology
  • Pre-Eclampsia / etiology*
  • Pre-Eclampsia / prevention & control
  • Pregnancy
  • Risk Factors
  • Selenium / analysis
  • Selenium / blood
  • Selenium / deficiency*
  • Selenium / therapeutic use
  • Selenoprotein P / blood
  • Toes
  • United Kingdom / epidemiology


  • Biomarkers
  • Selenoprotein P
  • Glutathione Peroxidase
  • Selenium