Nootropic dipeptide noopept enhances inhibitory synaptic transmission in the hippocampus

Bull Exp Biol Med. 2015 Jan;158(3):349-51. doi: 10.1007/s10517-015-2759-2. Epub 2015 Jan 9.

Abstract

Application of nootropic agent Noopept on hippocampal slices from Wistar rats enhanced the inhibitory component of total current induced by stimulation of Shaffer collaterals in CA1 pyramidal neurons, but did not affect the excitatory component. A direct correlation between the increase in the amplitude of inhibitory current and agent concentration was found. The substance did not affect the release of inhibitory transmitters from terminals in the pyramidal neurons, which indicated changes in GABAergic interneurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dipeptides / pharmacology*
  • Hippocampus / drug effects*
  • Hippocampus / metabolism*
  • Interneurons / drug effects
  • Interneurons / metabolism
  • Nootropic Agents / pharmacology*
  • Rats
  • Rats, Wistar
  • Synaptic Transmission / drug effects*

Substances

  • Dipeptides
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly