Recurrent polymyositis-associated lung disease after lung transplantation

Interact Cardiovasc Thorac Surg. 2015 Apr;20(4):560-2. doi: 10.1093/icvts/ivu423. Epub 2015 Jan 7.


The association between interstitial lung disease and polymyositis/dermatomyositis is well known. It severely affects patients' quality of life, worsens prognosis and represents a major risk factor for premature death. Current treatment is unclear and therapeutic options are based on case series. We report the case of a 15-year old female diagnosed with end-stage lung disease associated to polymyositis who received a double lung transplant after 20 days of extracorporeal membrane oxygenation. She died 9 months later and microscopic post-mortem findings revealed recurrence of interstitial lung disease. This is the first time that recurrence of polymyositis-associated lung disease following lung transplantation is described in the literature.

Keywords: Extracorporeal membrane oxygenation; Lung transplantation; Polymyositis; Pulmonary fibrosis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Fatal Outcome
  • Female
  • Humans
  • Lung Diseases, Interstitial / diagnosis
  • Lung Diseases, Interstitial / etiology
  • Lung Diseases, Interstitial / surgery*
  • Lung Transplantation / adverse effects*
  • Polymyositis / complications
  • Polymyositis / diagnosis
  • Polymyositis / surgery*
  • Recurrence
  • Time Factors
  • Tomography, X-Ray Computed