Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 19 (4), 309-17

The Diagnostic Validity of the (13)c-urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study

Affiliations

The Diagnostic Validity of the (13)c-urea Breath Test in the Gastrectomized Patients: Single Tertiary Center Retrospective Cohort Study

Yong Hwan Kwon et al. J Cancer Prev.

Abstract

Background: This study was conducted to evaluate the diagnostic validity of the (13)C-urea breath test ((13)C-UBT) in the remnant stomach after partial gastrectomy for gastric cancer.

Methods: The (13)C-UBT results after Helicobacter pylori eradication therapy was compared with the results of endoscopic biopsy-based methods in the patients who have received partial gastrectomy for the gastric cancer.

Results: Among the gastrectomized patients who showed the positive (13)C-UBT results (≥ 2.5‰, n = 47) and negative (13)C-UBT results (< 2.5‰, n = 114) after H. pylori eradication, 26 patients (16.1%) and 4 patients (2.5%) were found to show false positive and false negative results based on biopsy-based methods, respectively. The sensitivity, specificity, false positive rate, and false negative rate for the cut-off value of 2.5‰ were 84.0%, 80.9%, 19.1%, and 16.0%, respectively. The positive and negative predictive values were 44.7% and 96.5%, respectively. In the multivariate analysis, two or more H. pylori eradication therapies (odds ratio = 3.248, 95% confidence interval= 1.088-9.695, P = 0.035) was associated with a false positive result of the (13)C-UBT.

Conclusions: After partial gastrectomy, a discordant result was shown in the positive (13)C-UBT results compared to the endoscopic biopsy methods for confirming the H. pylori status after eradication. Additional endoscopic biopsy-based H. pylori tests would be helpful to avoid unnecessary treatment for H. pylori eradication in these cases.

Keywords: 13C-urea breath test; Cut-off value; Eradication; Helicobacter pylori; Subtotal gastrectomy.

Figures

Figure 1.
Figure 1.
Flow chart of 13C-urea breath test (13C-UBT) and endoscopic biopsy based results of Helicobacter pylori (H. pylori) status after eradication in the partial gastrectomized patients. CLO, rapid urease test (Campylobacter-like organism).
Figure 2.
Figure 2.
Individual values of the false positive 13C-urea breath test (13C-UBT) results after Helicobacter pylori (H. pylori) eradication in the partial gastrectomized patients (median 13C-UBT value = 5.9‰).

Similar articles

See all similar articles

Cited by 5 PubMed Central articles

References

    1. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med. 2002;347:1175–86. doi: 10.1056/NEJMra020542. - DOI - PubMed
    1. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology. 2007;133:659–72. doi: 10.1053/j.gastro.2007.06.026. - DOI - PubMed
    1. Matysiak-Budnik T, Megraud F. Helicobacter pylori infection and gastric cancer. Eur J Cancer. 2006;42:708–16. doi: 10.1016/j.ejca.2006.01.020. - DOI - PubMed
    1. Hopkins RJ, Girardi LS, Turney EA. Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology. 1996;110:1244–52. doi: 10.1053/gast.1996.v110.pm8613015. - DOI - PubMed
    1. Kwon YH, Heo J, Lee HS, Cho CM, Jeon SW. Failure of Helicobacter pylori eradication and age are independent risk factors for recurrent neoplasia after endoscopic resection of early gastric cancer in 283 patients. Aliment Pharmacol Ther. 2014;39:609–18. doi: 10.1111/apt.12633. - DOI - PubMed

LinkOut - more resources

Feedback