PLEKHM1: a multiprotein adaptor for the endolysosomal system

Moran Rawet-Slobodkin; Zvulun Elazar

doi:10.1016/j.molcel.2014.12.022

PLEKHM1: a multiprotein adaptor for the endolysosomal system

Mol Cell. 2015 Jan 8;57(1):1-3. doi: 10.1016/j.molcel.2014.12.022.

Authors

Moran Rawet-Slobodkin¹, Zvulun Elazar²

Affiliations

¹ Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
² Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: zvulun.elazar@weizmann.ac.il.

PMID: 25574946
DOI: 10.1016/j.molcel.2014.12.022

Abstract

Two papers by McEwan et al. (McEwan et al., 2015a, 2015b) identify interactions of PLEKHM1 with autophagosome-associated Atg8 proteins and Salmonella typhimurium effector, SifA, linking autophagy and the Salmonella-containing vacuole (SCV) to the endolysosomal Rab7/HOPS-regulated tethering machinery.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Animals
Apoptosis Regulatory Proteins
Autophagy-Related Proteins
Humans
Lysosomes / metabolism*
Membrane Fusion / genetics*
Membrane Glycoproteins / genetics*
Microtubule-Associated Proteins / genetics*
Phagosomes / metabolism*

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
Autophagy-Related Proteins
GABARAP protein, human
MAP1LC3A protein, human
Membrane Glycoproteins
Microtubule-Associated Proteins
PLEKHM1 protein, human