F-class cells: new routes and destinations for induced pluripotency

Cell Stem Cell. 2015 Jan 8;16(1):9-10. doi: 10.1016/j.stem.2014.12.007.


A series of five related publications describe an alternative pluripotent state that is dependent on continuous high levels of exogenous reprogramming factor expression. A comprehensive effort to molecularly compare the acquisition of this state to induced pluripotency aims at providing new insights into the mechanisms underlying cellular reprogramming.