F-class cells: new routes and destinations for induced pluripotency

Simon E Vidal; Matthias Stadtfeld; Eftychia Apostolou

doi:10.1016/j.stem.2014.12.007

F-class cells: new routes and destinations for induced pluripotency

Cell Stem Cell. 2015 Jan 8;16(1):9-10. doi: 10.1016/j.stem.2014.12.007.

Authors

Simon E Vidal¹, Matthias Stadtfeld², Eftychia Apostolou³

Affiliations

¹ The Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
² The Helen L. and Martin S. Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA. Electronic address: matthias.stadtfeld@med.nyu.edu.
³ Division of Hematology/Oncology, Department of Medicine and Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA. Electronic address: efa2001@med.cornell.edu.

PMID: 25575077
DOI: 10.1016/j.stem.2014.12.007

Abstract

A series of five related publications describe an alternative pluripotent state that is dependent on continuous high levels of exogenous reprogramming factor expression. A comprehensive effort to molecularly compare the acquisition of this state to induced pluripotency aims at providing new insights into the mechanisms underlying cellular reprogramming.

Grants and funding

R01 GM111852/GM/NIGMS NIH HHS/United States