Clonal evolution in cancer: a tale of twisted twines

Cell Stem Cell. 2015 Jan 8;16(1):11-2. doi: 10.1016/j.stem.2014.12.011.


Intra-tumor heterogeneity of cancer cells hampers the design of effective therapies and yet it is poorly reproduced in experimental models. A recent report by Eirew at al. provides an in-depth analysis of genetic heterogeneity of breast tumor xenografts and shows that changes in clonal diversity might not be stochastic.

Publication types

  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • Clone Cells / metabolism*
  • Clone Cells / pathology*
  • Genome, Human / genetics*
  • Humans
  • Single-Cell Analysis*
  • Xenograft Model Antitumor Assays*