Clonal evolution in cancer: a tale of twisted twines

Michalina Janiszewska; Kornelia Polyak

doi:10.1016/j.stem.2014.12.011

Clonal evolution in cancer: a tale of twisted twines

Cell Stem Cell. 2015 Jan 8;16(1):11-2. doi: 10.1016/j.stem.2014.12.011.

Authors

Michalina Janiszewska¹, Kornelia Polyak²

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
² Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address: kornelia_polyak@dfci.harvard.edu.

PMID: 25575078
DOI: 10.1016/j.stem.2014.12.011

Abstract

Intra-tumor heterogeneity of cancer cells hampers the design of effective therapies and yet it is poorly reproduced in experimental models. A recent report by Eirew at al. provides an in-depth analysis of genetic heterogeneity of breast tumor xenografts and shows that changes in clonal diversity might not be stochastic.

Publication types

Comment

MeSH terms

Animals
Breast Neoplasms / genetics*
Breast Neoplasms / pathology*
Clone Cells / metabolism*
Clone Cells / pathology*
Genome, Human / genetics*
Humans
Single-Cell Analysis*
Xenograft Model Antitumor Assays*