Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies

Cell Stem Cell. 2015 Jan 8;16(1):13-7. doi: 10.1016/j.stem.2014.12.013.


Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Culture Techniques / methods*
  • Cellular Reprogramming*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Reproducibility of Results
  • Stem Cell Transplantation