Interventional differences among Huntington's disease patients by disease progression in commercial and medicaid populations

J Huntingtons Dis. 2014;3(4):355-63. doi: 10.3233/JHD-140124.


Background: Huntington's disease (HD) is a progressive neurodegenerative disease that spans distinct disease stages over 15-20 years. Various interventions are available which may allow patients to live outside of a nursing home for a longer time. However, little is known about use of these interventions by disease stage and by insurance type.

Objective: We compared use of interventions among early, middle and late stages of HD in commercial (C) and Medicaid (M) health insurance populations.

Methods: HD patients (ICD-9-CM 333.4) were identified from Thomson Reuters' MarketScan C and M database (2002-2009) and hierarchically grouped into disease stages based upon the presence of defining clinical markers.

Results: A total of 1,272 HD patients (752/520 C/M) were identified. While stage distribution was nearly uniform in the C database - 34.0/35.5/34.0% (early/middle/late stage) - in the M population the majority were late stage (74.0%). Overall mean age was similar between C and M populations. Among late-stage patients, more M patients resided in a nursing home (M:73.8% v. C:40.6%) and received hospice care (M:18.4% v. C:11.3%). Physical therapy (PT) and home assistance were the most frequent interventions used by middle-stage patients, however more C patients received PT (C:64.0% v. M:37.1%) while more M patients received home assistance (M:75.3% v. C:53.2%). Among late-stage patients, PT was also higher in the C population (56.3% v. 48.3%). More M patients had assistive devices at home in both middle (M:25.8% v. C:9.7%) and late stages (M:35.6% v.C:23.4%).

Conclusions: Apparent interventional differences emerged which varied by disease stage and insurance type.

Keywords: Huntington's disease; databases; factual; health services/utilization*; insurance coverage; medicaid; retrospective studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Databases, Factual
  • Disease Progression
  • Female
  • Humans
  • Huntington Disease / economics
  • Huntington Disease / epidemiology*
  • Huntington Disease / therapy*
  • Insurance, Health / statistics & numerical data*
  • Male
  • Medicaid / statistics & numerical data*
  • Middle Aged
  • Retrospective Studies
  • United States / epidemiology
  • Young Adult