Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan;26(1):5331.
doi: 10.1007/s10856-014-5331-0. Epub 2015 Jan 11.

The Effect of Bone Marrow Concentrate and Hyperbaric Oxygen Therapy on Bone Repair

Affiliations

The Effect of Bone Marrow Concentrate and Hyperbaric Oxygen Therapy on Bone Repair

J P Grassmann et al. J Mater Sci Mater Med. .

Abstract

Neoangiogenesis represents an essential part of bone regeneration. Therefore the improvement of neovascularization is the subject of various research approaches. In addition autologous mesenchymal stem cells concentrate in combination with bone substitute materials have been shown to support bone regeneration. In a rabbit model we examined the proposed synergistic effect of hyperbaric oxygen therapy (HBOT) and bone marrow concentrate (BMC) with porous calcium phosphate granules (CPG) on neoangiogenesis and osseous consolidation of a critical- size defect. The animal groups treated with HBOT showed a significantly higher microvessel density (MVD) by immunhistochemistry. Furthermore HBOT groups presented a significantly larger amount of new bone formation histomorphometrically as well as radiologically. We conclude that the increase in perfusion as a result of increased angiogenesis may play a key role in the effects of HBOT and consequently promotes bone healing.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Ciba Found Symp. 1988;136:42-60 - PubMed
    1. J Orthop Trauma. 1989;3(3):192-5 - PubMed
    1. Int Endod J. 2009 Jun;42(6):463-75 - PubMed
    1. Blood. 1980 Aug;56(2):289-301 - PubMed
    1. J Orthop Trauma. 1999 Mar-Apr;13(3):187-95 - PubMed

Publication types

LinkOut - more resources

Feedback