Effects of Celiprolol and Bisoprolol on Blood Pressure, Vascular Stiffness, and Baroreflex Sensitivity

Am J Hypertens. 2015 Jul;28(7):858-67. doi: 10.1093/ajh/hpu245. Epub 2015 Jan 10.


Background: We tested the hypothesis that celiprolol and bisoprolol have differential effects on blood pressure (BP), flow-mediated dilation (FMD), and vascular stiffness.

Methods: We analyzed 102 hypertensives (mean age: 59±14 years) who were being treated other than beta-blockers. They were randomized to receive add-on treatment with either celiprolol 100-200mg (C group) or bisoprolol 2.5-5mg (B group), and followed up for 3 months. In addition to clinic, home, and ambulatory BP monitoring, the FMD, radial augmentation index (AI), brachial-ankle pulse wave velocity (baPWV), urine albumin-to-creatinine ratio, and baroreflex sensitivity (BRS) were measured at baseline and at the end of the study.

Results: Compared to the baseline values, home and 24-hour BP were significantly lowered in the third month in both groups (all Ps < 0.05). Pulse rate (PR) and baPWV were reduced (P < 0.001), and BRS was increased significantly only in the B group (P = 0.02). Radial AI was unchanged in the C group but was significantly increased in the B group (P < 0.001). Central BP was significantly reduced in the C group (P = 0.003) but was unchanged in the B group. FMD was significantly increased in both groups (both P < 0.01).

Conclusion: Bisoprolol achieved the greater reduction of PR and improved BRS and vascular stiffness, whereas, celiprolol reduced the central BP level. In treated hypertensive patients, add-on use of celiprolol may be favorable in uncomplicated stage of hypertension. On the other hand, bisoprolol may be useful in hypertensives with cardiac or vascular diseases who have advanced atherosclerotic changes and sympathetic nervous system activation.

Keywords: ambulatory BP; bisoprolol; blood pressure; celiprolol; central BP; flow-mediated vasodilation; home BP; hypertension; pulse wave velocity; urinary albumin excretion ratio..

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adrenergic beta-1 Receptor Antagonists / adverse effects
  • Adrenergic beta-1 Receptor Antagonists / therapeutic use*
  • Adult
  • Aged
  • Ankle Brachial Index
  • Antihypertensive Agents / adverse effects
  • Antihypertensive Agents / therapeutic use*
  • Baroreflex / drug effects*
  • Bisoprolol / adverse effects
  • Bisoprolol / therapeutic use*
  • Blood Pressure / drug effects*
  • Blood Pressure Monitoring, Ambulatory
  • Celiprolol / adverse effects
  • Celiprolol / therapeutic use*
  • Female
  • Humans
  • Hypertension / diagnosis
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Japan
  • Male
  • Middle Aged
  • Patient Selection
  • Predictive Value of Tests
  • Prospective Studies
  • Pulse Wave Analysis
  • Time Factors
  • Treatment Outcome
  • Vascular Stiffness / drug effects*


  • Adrenergic beta-1 Receptor Antagonists
  • Antihypertensive Agents
  • Celiprolol
  • Bisoprolol