Effects of bicarbonate-containing versus lactate-containing peritoneal dialysis solutions on superoxide production by human neutrophils

Artif Organs. 1989 Dec;13(6):495-7. doi: 10.1111/j.1525-1594.1989.tb01568.x.


Human neutrophils were isolated from healthy volunteers and exposed to either bicarbonate-containing (pH 7.4) or lactate-containing (pH 5.2) peritoneal dialysis solution in vitro. Superoxide production by neutrophils was measured by a method based on the superoxide dismutase-inhibitable reduction of ferricytochrome c. Bicarbonate-containing peritoneal dialysis solution was found to be superior to the lactate-containing one in facilitating the production of superoxide anion by human neutrophils.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Bicarbonates / pharmacology*
  • Dialysis Solutions / pharmacology*
  • Humans
  • In Vitro Techniques
  • Lactates / pharmacology*
  • Lactic Acid
  • Neutrophils / drug effects*
  • Neutrophils / metabolism
  • Peritoneal Dialysis
  • Superoxides / metabolism*


  • Bicarbonates
  • Dialysis Solutions
  • Lactates
  • Superoxides
  • Lactic Acid