The effect of aluminum and gallium ions on the mineralization process

Bull Hosp Jt Dis Orthop Inst. Fall 1989;49(2):192-204.


Metal ions have various and significant effects on the skeletal system. Aluminum accumulation in renal dialysis patients causes osteomalacia, while gallium is an effective therapeutic agent for treating the hypercalcemia accompanying certain malignancies. Using in-vitro systems that stimulate in-vivo mineralization, the authors have investigated the physical-chemical mechanisms of the actions of aluminum and gallium and report some of their findings.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adsorption
  • Aluminum / pharmacology*
  • Gallium / pharmacology*
  • Hydroxyapatites / metabolism*
  • In Vitro Techniques
  • Ions
  • Solubility


  • Hydroxyapatites
  • Ions
  • Gallium
  • Aluminum