Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization

Brain Res. 1989 Dec 4;503(2):299-303. doi: 10.1016/0006-8993(89)91678-8.


The distribution of Insulin-like growth factor 1 (IGF-1) receptors in large cryosections of human brain hemispheres (80-microns) was studied by quantitative autoradiography using 125I-IGF-1 as ligand. Postmortem tissue only from individuals free from neurological diseases was used. The highest densities of IGF-1 receptors were found in the hippocampus, amygdala and parahippocampal gyrus. Intermediate densities were observed in the cerebellum, cerebral cortex and caudate nucleus, whereas low densities of IGF-1 receptors were obtained in the substantia nigra, red nucleus, white matter and cerebral pedunculus. The cartography of IGF-1 receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Autoradiography
  • Brain / metabolism*
  • Humans
  • Insulin-Like Growth Factor I / metabolism
  • Male
  • Middle Aged
  • Receptors, Cell Surface / metabolism*
  • Receptors, Somatomedin


  • Receptors, Cell Surface
  • Receptors, Somatomedin
  • Insulin-Like Growth Factor I