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Review
. 2015 Jan 8;20(1):929-50.
doi: 10.3390/molecules20010929.

Activity of Alkaloids on Peptic Ulcer: What's New?

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Free PMC article
Review

Activity of Alkaloids on Peptic Ulcer: What's New?

Raphaela Francelino do Nascimento et al. Molecules. .
Free PMC article

Abstract

Peptic ulcer is a common disease characterized by lesions that affect the mucosa of the esophagus, stomach and/or duodenum, and may extend into the muscular layer of the mucosa. Natural products have played an important role in the process of development and discovery of new drugs, due to their wide structural diversity and present, mostly specific and selective biological activities. Among natural products the alkaloids, biologically active secondary metabolites, that can be found in plants, animals or microorganisms stand out. The alkaloids are compounds consisting of a basic nitrogen atom that may or may not be part of a heterocyclic ring. This review will describe 15 alkaloids with antiulcer activity in animal models and in vitro studies.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Rutaecarpine.
Figure 2
Figure 2
2-Phenylquinoline.
Figure 3
Figure 3
Nicotine.
Figure 4
Figure 4
Rohitukine.
Figure 5
Figure 5
2-Methoxycanthin-6-one.
Figure 6
Figure 6
Chelerythrine chloride.
Figure 7
Figure 7
Piplartine.
Figure 8
Figure 8
N-Isopropylmethylanthranilate.
Figure 9
Figure 9
N-Methylmethylanthranilate.
Figure 10
Figure 10
(+)-O-Methylarmepavine.
Figure 11
Figure 11
N-Methylcorydaldine.
Figure 12
Figure 12
Isocorydine.
Figure 13
Figure 13
Cathin-6-one.
Figure 14
Figure 14
Peganine.
Figure 15
Figure 15
4–Guanidinobutyric acid.

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References

    1. Najim W.I. Peptic ulcer disease. Prim. Care Clin. 2012;38:383–394. doi: 10.1016/j.pop.2011.05.001. - DOI - PubMed
    1. Nieto Y.B. Úlcera péptica. Medicine. 2012;11:137–141.
    1. Lau J.Y., Sung J., Hill C., Henderson C., Howden C.W., Metz D.C. Systematic review of the epidemiology of complicated peptic ulcer disease: Incidence, recurrence, risk factors and mortality. Digestion. 2011;84:102–113. doi: 10.1159/000323958. - DOI - PubMed
    1. Groenen M.J.M., Kuipers E.J., Hanses B.E., Ouwendijk R.J.T. Incidence of duodenal ulcers and gastric ulcers in a Western population: Back to where it started. Can. J. Gastroenterol. 2009;23:604–608. - PMC - PubMed
    1. Harold K., Grant D., Mitchel J. Principles of Medical Pharmacology. 7th ed. Elsevier; Toronto, ON, Canada: 2007. Pharmacotherapy of acid peptic disorders; pp. 558–559.

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