Traumatic brain injury in 2014. Progress, failures and new approaches for TBI research

Nat Rev Neurol. 2015 Feb;11(2):71-2. doi: 10.1038/nrneurol.2014.261. Epub 2015 Jan 13.


The past year saw the 40th anniversary of the Glasgow Coma Scale, which continues to be effective for monitoring patients with traumatic brain injury. Three new clinical trials were completed, but none revealed beneficial interventions. These failures have prompted exploration of more-subtle therapy targets, novel disease classifications and collaborative research paradigms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Injuries* / diagnosis
  • Brain Injuries* / drug therapy
  • Glasgow Coma Scale
  • Humans
  • Randomized Controlled Trials as Topic
  • Research
  • Severity of Illness Index