Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization

J Am Chem Soc. 2015 Feb 4;137(4):1404-7. doi: 10.1021/ja512242d. Epub 2015 Jan 26.


Parahydrogen is demonstrated to efficiently transfer its nuclear spin hyperpolarization to nitrogen-15 in pyridine and nicotinamide (vitamin B(3) amide) by conducting "signal amplification by reversible exchange" (SABRE) at microtesla fields within a magnetic shield. Following transfer of the sample from the magnetic shield chamber to a conventional NMR spectrometer, the (15)N NMR signals for these molecules are enhanced by ∼30,000- and ∼20,000-fold at 9.4 T, corresponding to ∼10% and ∼7% nuclear spin polarization, respectively. This method, dubbed "SABRE in shield enables alignment transfer to heteronuclei" or "SABRE-SHEATH", promises to be a simple, cost-effective way to hyperpolarize heteronuclei. It may be particularly useful for in vivo applications because of longer hyperpolarization lifetimes, lack of background signal, and facile chemical-shift discrimination of different species.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Hydrogen / chemistry*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Niacinamide / chemistry*
  • Nitrogen Isotopes / analysis*
  • Pyridines / chemistry*


  • Nitrogen Isotopes
  • Pyridines
  • Niacinamide
  • Hydrogen
  • pyridine