Effect of neurokinin A on human temporal muscle blood flow

Peptides. Sep-Oct 1989;10(5):921-4. doi: 10.1016/0196-9781(89)90169-1.


The effect of neurokinin A on human temporal muscle blood flow was compared to saline when injected into the muscle in six normal subjects. The 133-Xenon washout technique was used and the test solutions administered in a double-blind, cross-over manner. Neurokinin A (0.02 ml, 10(-5)M) caused a blood flow increase of 193%, while saline caused an increase of 23%. The difference between neurokinin A and saline was significant (p less than 0.05). It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Blood Pressure / drug effects
  • Double-Blind Method
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Mastication / physiology
  • Masticatory Muscles / drug effects*
  • Neurokinin A / pharmacology*
  • Regional Blood Flow / drug effects
  • Temporal Muscle / blood supply
  • Temporal Muscle / drug effects*


  • Neurokinin A