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. 2014 Nov;8(11):MC01-6.
doi: 10.7860/JCDR/2014/10301.5141. Epub 2014 Nov 20.

A Double-Blind, Rct Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?

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A Double-Blind, Rct Testing Beneficial Modulation of BDNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?

D H Chui et al. J Clin Diagn Res. .
Free PMC article

Abstract

Introduction: The aim of this prospective study was to see whether LD-1227, a quality-controlled marine nutraceuticals shown to protect experimental stress-induced hyppocampal degeneration, could beneficially modulate BDNF, as measured in the serum, in otherwise healthy but work-stressed individuals.

Materials and methods: Forty-eight men and women between the ages of 38 and 62 reporting high-demanding work activity but with an overall positive attitude towards their personal life were recruited. Subjects were divided in two group (24 patients each) and blindly supplemented for 2 month with: a) LD-1227 400mg or b) placebo. A third group of healthy non-stressed subjects was used as well. Blood samples were taken before and after the supplementation period. Unstimulated saliva was collected and tested for amylase while serum levels were used to measure BDNF. State Trait Anxiety Inventory (STAI), Pittsburgh Sleep Quality Index (PSQI) and psychological well-being assessment (PSWB) were measured too. Patients with Val66Met functional polymorphism of BDNF excluded those given their reported association with an impaired release of BDNF.

Results: RESULTS showed that, as compared to healthy, non-stressed individuals, stressed ones has a trend decrease of BDNF and this was significantly increased by LD 12-1227 supplementation and the same inverse phenomenon occurred to salivary amylase (p<0.05). No change was noted in the PSQI score but, either STAI or PSWB tests scored better in LD-1227 supplemented subjects.

Conclusion: The present data suggest that LD-1227 is beneficially affecting neuromodulation and related symptoms during common stressful life conditions and may have the potential as tools in a neuroprotective clinical strategy.

Keywords: LD-1227; Neurogenesis; Neuroprotection; Stress-induced neurodegeneration.

Figures

[Table/Fig-3]:
[Table/Fig-3]:
State Anxiety Score: absolute change during LD-1227 supplem-entation., * p<0.05 vs stressed placebo-supplemented controls
[Table/Fig-4a]:
[Table/Fig-4a]:
Psychological well-being assessment during LD-1227 supplementation. Effect on absolute score change for: Alertness [Table/Fig-4a], Contentedness.,and Calmness When analyzing this parameter taking into account only the first half-day evaluation, this phenomenon reached a significant statistical values (group C vs placebo, p<0.005, see text) ns: not sstatistically significant; * p<0.05 vs stressed placebo-supplemented subjects
[Table/Fig-5]:
[Table/Fig-5]:
Effect of LD-1227 supplementation on salivary amylase, * p<0.05 vs stressed placebo-supplemented controls; ** p<0.01 vs healthy not stressed control subjects
[Table/Fig-6]:
[Table/Fig-6]:
Effect of LD-1227 supplementation on serum BDNF during 2 months observation study., * p<0.05 vs own baseline values and vs stressed placebo-supplemented subjects

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