Robo3: the road taken

Ian V Beamish; Timothy E Kennedy

doi:10.1016/j.devcel.2014.12.021

Robo3: the road taken

Dev Cell. 2015 Jan 12;32(1):3-4. doi: 10.1016/j.devcel.2014.12.021.

Authors

Ian V Beamish¹, Timothy E Kennedy²

Affiliations

¹ Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada.
² Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada. Electronic address: timothy.kennedy@mcgill.ca.

PMID: 25584792
DOI: 10.1016/j.devcel.2014.12.021

Abstract

Although axon guidance mechanisms are well conserved across the animal kingdom, neuronal circuit complexity increases dramatically in evolution. Reporting recently in Neuron, Zelina et al. (2014) uncover mammalian-specific changes in Robo3 that result in a switch from repellent to attractive signaling and may have contributed to increased mammalian circuit complexity.

Publication types

Comment

MeSH terms

Animals
Axons / metabolism*
Biological Evolution*
Humans
Membrane Proteins / metabolism*
Nerve Tissue Proteins / metabolism*
Receptors, Cell Surface / metabolism*
Signal Transduction*

Substances

Membrane Proteins
Nerve Tissue Proteins
Receptors, Cell Surface