Making sense of anti-sense data

Dev Cell. 2015 Jan 12;32(1):7-8. doi: 10.1016/j.devcel.2014.12.012.


The morpholino anti-sense technology has been used extensively to test gene function. The zebrafish model allows a detailed comparison of knockdown (anti-sense) and knockout (mutation) effects. Recent studies reveal that these two approaches can often lead to surprisingly different phenotypes, thus raising a number of important questions.

MeSH terms

  • Animals
  • Gene Expression Regulation / drug effects*
  • Gene Knockdown Techniques / methods*
  • Morpholinos / pharmacology*
  • Oligonucleotides, Antisense / pharmacology*
  • Phenotype
  • Zebrafish / genetics*
  • Zebrafish Proteins / antagonists & inhibitors
  • Zebrafish Proteins / genetics*


  • Morpholinos
  • Oligonucleotides, Antisense
  • Zebrafish Proteins