Vascular-promoting Therapy Reduced Tumor Growth and Progression by Improving Chemotherapy Efficacy

Cancer Cell. 2015 Jan 12;27(1):7-9. doi: 10.1016/j.ccell.2014.12.009.

Abstract

In this issue of Cancer Cell, Wong and colleagues describe a novel approach of increasing the number of functional blood vessels in tumors using a low-dose therapy regimen of Cilengtide and Verapamil. This method enhanced gemcitabine delivery, uptake, and metabolism within tumor cells to reduce tumor growth and progression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Carcinoma, Lewis Lung / drug therapy*
  • Carcinoma, Lewis Lung / pathology*
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives*
  • Humans
  • Pancreatic Neoplasms / drug therapy*
  • Snake Venoms / administration & dosage*
  • Verapamil / administration & dosage*

Substances

  • Antimetabolites, Antineoplastic
  • Snake Venoms
  • Deoxycytidine
  • Cilengitide
  • gemcitabine
  • Verapamil