Florid papillomatosis of the nipple: a rare presentation and review of the literature

Breast Dis. 2015;35(2):153-6. doi: 10.3233/BD-150397.


Florid papillomatosis (FP) of the nipple, or nipple adenoma, is a rare benign proliferative lesion originating from the lactiferous ducts of the nipple. It most commonly affects women in their fourth and fifth decades of life. Clinically, in most cases FP presents with serous or serosanguinous nipple discharge while in many cases an erythematoid or eroded lesion, a nodule or a swelling of the nipple may coexist thus resembling Paget's disease. We describe a case of FP with a very unusual clinical presentation. Diagnostic evaluation and management of the patient are discussed along with a review of the relevant literature. We conclude that FP should be always considered in the differential diagnosis of patients presenting with a rapidly enlarging nipple nodule even in the absence of any skin lesions or nipple discharge. Early diagnosis and prompt treatment are essential. Simple complete excision in order to eliminate the risk of recurrence is the treatment of choice for FP. Although in rare cases a coincidental ipsilateral or contralateral breast cancer has been reported, FP is considered as an entirely benign clinical entity associated with excellent prognosis.

Keywords: Florid papillomatosis; adenoma; nipple.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Breast Neoplasms / diagnosis*
  • Diagnosis, Differential
  • Female
  • Humans
  • Paget's Disease, Mammary / diagnosis*
  • Papilloma / diagnosis*
  • Tubular Sweat Gland Adenomas
  • Young Adult