Abstract
Selective uptake of the cerebral blood-flow imaging agent 99mTc-hexamethylpropyleneamine oxime (HM-PAO) by Human Herpesvirus 1 (HSV-1) infected cells was investigated in vivo and in vitro. No specific uptake of HM-PAO was observed either in encephalitic rats (by brain scintigraphic imaging or by immunoperoxidase staining/autoradiography of brain sections) or in HSV-1 infected Vero cells.
MeSH terms
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Animals
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Antiviral Agents / pharmacology
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Autoradiography
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Brain / metabolism
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Disease Models, Animal
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Encephalitis / diagnostic imaging*
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Encephalitis / etiology
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Female
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Herpesviridae Infections / diagnostic imaging*
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Humans
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Immunoenzyme Techniques
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Organotechnetium Compounds / pharmacokinetics*
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Oximes / pharmacokinetics*
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Radionuclide Imaging
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Rats
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Rats, Inbred Strains
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Simplexvirus / metabolism*
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Technetium Tc 99m Exametazime
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Vero Cells
Substances
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Antiviral Agents
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Organotechnetium Compounds
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Oximes
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Technetium Tc 99m Exametazime