HM-PAO-imaging and herpes encephalitis

Arch Virol. 1989;109(3-4):263-8. doi: 10.1007/BF01311086.

Abstract

Selective uptake of the cerebral blood-flow imaging agent 99mTc-hexamethylpropyleneamine oxime (HM-PAO) by Human Herpesvirus 1 (HSV-1) infected cells was investigated in vivo and in vitro. No specific uptake of HM-PAO was observed either in encephalitic rats (by brain scintigraphic imaging or by immunoperoxidase staining/autoradiography of brain sections) or in HSV-1 infected Vero cells.

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology
  • Autoradiography
  • Brain / metabolism
  • Disease Models, Animal
  • Encephalitis / diagnostic imaging*
  • Encephalitis / etiology
  • Female
  • Herpesviridae Infections / diagnostic imaging*
  • Humans
  • Immunoenzyme Techniques
  • Organotechnetium Compounds / pharmacokinetics*
  • Oximes / pharmacokinetics*
  • Radionuclide Imaging
  • Rats
  • Rats, Inbred Strains
  • Simplexvirus / metabolism*
  • Technetium Tc 99m Exametazime
  • Vero Cells

Substances

  • Antiviral Agents
  • Organotechnetium Compounds
  • Oximes
  • Technetium Tc 99m Exametazime