T-cell cytokine gene polymorphisms and vitamin D pathway gene polymorphisms in end-stage renal disease due to type 2 diabetes mellitus nephropathy: comparisons with health status and other main causes of end-stage renal disease

J Diabetes Res. 2014:2014:120317. doi: 10.1155/2014/120317. Epub 2014 Dec 22.


Background: T-cell cytokine gene polymorphisms and vitamin D pathway gene polymorphisms were evaluated as possibly associated with end-stage renal disease (ESRD) resulting from type 2 diabetes mellitus (DM) nephropathy.

Methods: Studies were conducted among hemodialysis (HD) patients with ESRD due to type 2 DM nephropathy, chronic glomerulonephritis, chronic infective tubulointerstitial nephritis, and hypertensive nephropathy as well as in healthy subjects. A frequency distribution of T-cell-related interleukin (IL) genes (IL18 rs360719, IL12A rs568408, IL12B rs3212227, IL4R rs1805015, IL13 rs20541, IL28B rs8099917, IL28B, and rs12979860) and vitamin D pathway genes (GC genes: rs2298849, rs7041, and rs1155563; VDR genes: rs2228570, rs1544410; and RXRA genes: rs10776909, rs10881578, and rs749759) was compared between groups.

Results: No significant differences in a frequency distribution of tested polymorphisms were shown between type 2 DM nephropathy patients and controls. A difference was found in IL18 rs360719 polymorphic distribution between the former group and chronic infective tubulointerstitial nephritic patients (P trend = 0.033), which also differed in this polymorphism from controls (P trend = 0.005).

Conclusion: T-cell cytokine and vitamin D pathway gene polymorphisms are not associated with ESRD due to type 2 DM nephropathy in Polish HD patients. IL18 rs360719 is probably associated with the pathogenesis of chronic infective tubulointerstitial nephritis.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Nephropathies / diagnosis
  • Diabetic Nephropathies / genetics*
  • Diabetic Nephropathies / immunology
  • Diabetic Nephropathies / therapy
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-18 / genetics
  • Interleukins / genetics*
  • Kidney Failure, Chronic / diagnosis
  • Kidney Failure, Chronic / genetics*
  • Kidney Failure, Chronic / immunology
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Phenotype
  • Poland
  • Polymorphism, Single Nucleotide*
  • Receptors, Calcitriol / genetics*
  • Renal Dialysis
  • Retinoid X Receptor alpha / genetics
  • Risk Factors
  • T-Lymphocytes / immunology*


  • Interleukin-18
  • Interleukins
  • Receptors, Calcitriol
  • Retinoid X Receptor alpha
  • VDR protein, human