Epigenetic modulation of metabolic decisions

Curr Opin Cell Biol. 2015 Apr;33:88-94. doi: 10.1016/j.ceb.2014.12.005. Epub 2015 Jan 10.

Abstract

In the recent years there has been a tremendous increase in our understanding of chromatin, transcription and the importance of metabolites in their regulation. This review highlights what is currently sparse information that suggest existence of a refined system integrating metabolic and chromatin control. We indicate possible regulatory modes, such as feed forward amplification, that may help effect and stabilize long-lasting phenotypic decisions within and even across generations using adipogenesis as the primary context.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / cytology
  • Adipocytes / metabolism
  • Adipogenesis / genetics
  • Animals
  • Chromatin / genetics
  • Chromatin / metabolism
  • Epigenesis, Genetic*
  • Humans
  • Metabolism / genetics*

Substances

  • Chromatin