Neural control of the lower urinary tract

Compr Physiol. 2015 Jan;5(1):327-96. doi: 10.1002/cphy.c130056.


This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Neuronal Plasticity / physiology
  • Neurons, Afferent / physiology
  • Neurotransmitter Agents / physiology
  • Peripheral Nervous System / anatomy & histology
  • Peripheral Nervous System / physiology
  • Reflex / physiology
  • Spinal Cord / physiology
  • Urethra / innervation
  • Urinary Bladder / innervation
  • Urinary Tract / innervation*
  • Urination / physiology*


  • Neurotransmitter Agents