Soluble fractalkine in the plasma of fibromyalgia patients

An Acad Bras Cienc. 2014 Dec;86(4):1915-7. doi: 10.1590/0001-3765201420130081. Epub 2014 Dec 9.


Fibromyalgia is a form of non-articular rheumatism in which inflammatory cytokines seem to be involved. However, there is still no analytical specific diagnostic criterion for this disease. The aim was to examine a possible role of fractalkine as a biomarker in fibromyalgia. Plasma levels of soluble fractalkine were compared between women diagnosed with fibromyalgia (n=17) and healthy women (n=10) as controls. Fractalkine released by monocytes was also evaluated. Fibromyalgia patients showed lower plasma fractalkine than healthy women. Since most inflammatory pathologies show elevated plasma levels of soluble fractalkine, the results may contribute towards a differential diagnosis for fibromyalgia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Case-Control Studies
  • Chemokine CX3CL1 / blood*
  • Female
  • Fibromyalgia / blood*
  • Fibromyalgia / diagnosis
  • Humans
  • Middle Aged


  • Biomarkers
  • Chemokine CX3CL1