Looking into Candida albicans infection, host response, and antifungal strategies

Virulence. 2015;6(4):307-8. doi: 10.1080/21505594.2014.1000752. Epub 2015 Jan 15.

Abstract

Candida albicans, a commonly encountered fungal pathogen, causes diseases varying from superficial mucosal complaints to life-threatening systemic disorders. Among the virulence traits of C. albicans, yeast-to-hypha transition is most widely acknowledged. Host innate immunity to C. albicans critically requires pattern recognition receptors (PRRs), and defence against C. albicans infection is provided by an exquisite interplay between the innate and adaptive arms of the host immune system.

Keywords: Candida albicans; antifungal; immune response.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity
  • Candida albicans / immunology*
  • Candida albicans / pathogenicity*
  • Candida albicans / physiology
  • Candidiasis / immunology*
  • Candidiasis / microbiology
  • Fungal Vaccines
  • Host-Pathogen Interactions*
  • Humans
  • Immunity, Innate

Substances

  • Fungal Vaccines