High degree of nonadherence to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis

J Rheumatol. 2015 Mar;42(3):386-90. doi: 10.3899/jrheum.140982. Epub 2015 Jan 15.

Abstract

Objective: To test medication adherence using the Compliance-Questionnaire-Rheumatology (CQR).

Methods: Invitation letter and CQR were sent to 240 patients with rheumatoid arthritis. Followup CQR was sent 3 months later. Adherence was evaluated using CQR 80% cutoff scores.

Results: Seventy-eight patients who were being treated with disease-modifying antirheumatic drugs provided full information on the CQR at both points in time. Eleven patients (14.1%) were classified as adherent based on taking compliance (TC), with only 3 patients (3.8%) adherent in regard to correct dosing (CD) [followup: 13 (16.7%) and 3 (3.8%) for TC and CD, respectively]. Nonadherence was not related to disease activity or side effects.

Conclusion: We demonstrated low adherence, suggesting differences between doctors' records and patients' practice of antirheumatic drug therapy.

Keywords: ADHERENCE; COMPLIANCE; CQR; DISEASE-MODIFYING ANTIRHEUMATIC DRUGS; RHEUMATOID ARTHRITIS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antirheumatic Agents / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy*
  • Female
  • Humans
  • Male
  • Medication Adherence / psychology
  • Medication Adherence / statistics & numerical data*
  • Middle Aged
  • Surveys and Questionnaires

Substances

  • Antirheumatic Agents