Coagulation takes center stage in inflammation

Blood. 2015 Jan 15;125(3):419-20. doi: 10.1182/blood-2014-11-609222.


In this issue of Blood, Raghu et al provide exciting new data implicating transglutaminase factor XIII (fXIII) in rheumatoid arthritis in mice. The study presents compelling evidence demonstrating that fXIII contributes to arthritis pathogenesis through distinct mechanisms linked to inflammation and destructive bone loss.

Publication types

  • Comment

MeSH terms

  • Animals
  • Arthritis, Experimental / pathology*
  • Bone Diseases / physiopathology*
  • Factor XIII / physiology*
  • Female
  • Inflammation / physiopathology*
  • Male
  • Osteoclasts / pathology*


  • Factor XIII