Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss

Obesity (Silver Spring). 2015 Feb;23(2):313-21. doi: 10.1002/oby.20966. Epub 2014 Dec 31.

Abstract

Objective: To evaluate the potential body weight-lowering effects of dietary supplementation with eicosapentaenoic acid (EPA) and α-lipoic acid separately or combined in healthy overweight/obese women following a hypocaloric diet.

Methods: This is a short-term double-blind placebo-controlled study with parallel design that lasted 10 weeks. Of the randomized participants, 97 women received the allocated treatment [Control, EPA (1.3 g/d), α-lipoic acid (0.3 g/d), and EPA+α-lipoic acid (1.3 g/d+0.3 g/d)], and 77 volunteers completed the study. All groups followed an energy-restricted diet of 30% less than total energy expenditure. Body weight, anthropometric measurements, body composition, resting energy expenditure, blood pressure, serum glucose, and insulin and lipid profile, as well as leptin and ghrelin levels, were assessed at baseline and after nutritional intervention.

Results: Body weight loss was significantly higher (P<0.05) in those groups supplemented with α-lipoic acid. EPA supplementation significantly attenuated (P<0.001) the decrease in leptin levels that occurs during weight loss. Body weight loss improved lipid and glucose metabolism parameters but without significant differences between groups.

Conclusions: The intervention suggests that α-lipoic acid supplementation alone or in combination with EPA may help to promote body weight loss in healthy overweight/obese women following energy-restricted diets.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Antioxidants / administration & dosage*
  • Body Composition
  • Cholesterol / blood
  • Dietary Supplements
  • Double-Blind Method
  • Drug Therapy, Combination
  • Eicosapentaenoic Acid / administration & dosage*
  • Eicosapentaenoic Acid / blood
  • Energy Metabolism
  • Female
  • Ghrelin / metabolism
  • Glucose / metabolism
  • Humans
  • Insulin / blood
  • Leptin / metabolism
  • Lipid Metabolism / drug effects
  • Middle Aged
  • Obesity / blood
  • Obesity / drug therapy*
  • Thioctic Acid / administration & dosage*
  • Thioctic Acid / blood
  • Treatment Outcome
  • Weight Loss*
  • Young Adult

Substances

  • Antioxidants
  • Ghrelin
  • Insulin
  • Leptin
  • Thioctic Acid
  • Cholesterol
  • Eicosapentaenoic Acid
  • Glucose