A protein restriction-dependent sulfur code for longevity

Cell. 2015 Jan 15;160(1-2):15-7. doi: 10.1016/j.cell.2014.12.027.


The restriction of proteins has recently emerged as the most important factor for the beneficial effects of calorie restriction. Hine et al. now provide strong evidence for the role of the hydrogen sulfide (H2S) gas in the protective effects of calorie and protein restriction against ischemia/reperfusion injury (IRI) but also implicate H2S in longevity extension in model organisms.

Publication types

  • Comment

MeSH terms

  • Animals
  • Diet*
  • Female
  • Hydrogen Sulfide / metabolism*
  • Male


  • Hydrogen Sulfide