SnapShot: Fanconi anemia and associated proteins

Cell. 2015 Jan 15;160(1-2):354-354.e1. doi: 10.1016/j.cell.2014.12.031.

Abstract

Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17 FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. The underlying cause is genomic instability resulting from the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors involved.

MeSH terms

  • Animals
  • DNA Repair*
  • Fanconi Anemia / metabolism*
  • Fanconi Anemia Complementation Group Proteins / chemistry
  • Fanconi Anemia Complementation Group Proteins / genetics
  • Fanconi Anemia Complementation Group Proteins / metabolism*
  • Humans

Substances

  • Fanconi Anemia Complementation Group Proteins